Acne can persist for many years, acting in a serious aesthetic problem, and often untreated - leaves disfiguring marks the end of life. In about 15 percent. acne patients have run heavy and require a general treatment. The underlying disease is the number of factors, including the genetic and increased sebum caused by hyperactivity of the sebaceous glands (which could be associated with increased androgen levels or an excessive sensitivity of the sebaceous glands of these hormones).
Hormonal disorders found to be quite rare and are the most common: adrenal hyperandrogenism or functional hyperprolactinemia. Seborrhea and rapid flow of sebum dissolve the lipid lives, lowers cholesterol, ceramides, and linoleic acid. This is one factor causing increased, abnormal keratinization ducts of the sebaceous glands and hair follicle, which leads to the formation of mikrozaskórników. A large role, in addition to disorders of keratinization of hair follicles, plays a relative deficiency of linoleic acid, release of inflammatory mediators in the skin and the presence of the bacteria Propionibacterium acnes.
